Polynucleotides
Regenerate your skin at a cellular level with DNA-based therapy that repairs, rejuvenates, and restores skin health from within.
What Are Polynucleotides?
Polynucleotides (PN) are cutting-edge bio-regenerative injectable treatments composed of highly purified DNA fragments derived from salmon or trout sperm. These naturally occurring molecules work at a cellular level to repair damaged tissue, stimulate collagen and elastin production, and restore skin health from within.
Unlike traditional dermal fillers that simply add volume, polynucleotides are true regenerative treatments that activate your skin's natural healing mechanisms, improve cellular function, and address the underlying causes of skin aging. They're particularly effective for improving skin quality, texture, hydration, and overall tissue health.
Polynucleotides have been used in medical applications for wound healing and tissue repair for years, and are now revolutionising aesthetic medicine with their powerful anti-aging and skin regenerating properties.
Popular Polynucleotide Products
Nucleofill (Medium, Strong, Eyes) Italian-made polynucleotide available in different concentrations for various treatment areas and concerns.
Plinest (Fast, Nanosoft) Premium polynucleotide formulations for comprehensive skin rejuvenation and bio-remodelling.
Ameela Advanced polynucleotide formula with high molecular weight for enhanced bio-stimulation.
Neauvia Hydro Deluxe Combines polynucleotides with hyaluronic acid for dual-action hydration and regeneration.
Lumi Eyes / Plinest Eyes Specialised formulations designed specifically for the delicate under-eye area.
How Polynucleotides Work
The Science:
Cellular Activation: When injected into the skin, polynucleotides are recognised by cells as DNA building blocks, triggering natural repair mechanisms
Fibroblast Stimulation: They activate fibroblast cells (the cells responsible for producing collagen and elastin) to increase production of these essential skin proteins
Anti-Inflammatory Action: Polynucleotides have powerful anti-inflammatory properties that calm irritated skin, reduce redness, and improve conditions like rosacea
Antioxidant Protection: They neutralise free radicals that cause premature aging and cellular damage
Tissue Repair: Promote healing at a cellular level, repairing damaged DNA and supporting healthy cell turnover
Hydration Enhancement: Improve the skin's ability to retain moisture and maintain optimal hydration levels
Vascular Improvement: Enhance microcirculation and blood flow, bringing more oxygen and nutrients to skin cells
Benefits of Polynucleotide Treatments
Bio-Regeneration at Cellular Level Works at the deepest level to repair cellular damage, restore healthy cell function, and genuinely regenerate tissue rather than just masking aging signs.
Anti-Inflammatory Properties Powerful anti-inflammatory effects make polynucleotides ideal for sensitive skin, rosacea, and inflammatory skin conditions that other treatments can't address.
Collagen and Elastin Stimulation Activates your skin's own production of collagen and elastin for progressive, natural improvement in firmness and elasticity.
Superior Hydration Improves skin's moisture retention capacity and hydration levels from within, creating plump, dewy, healthy-looking skin.
Antioxidant Protection Neutralises free radicals and protects against environmental damage, pollution, and UV exposure that accelerate aging.
Skin Barrier Repair Strengthens and repairs the skin barrier, improving resilience, reducing sensitivity, and protecting against external aggressors.
Versatile Applications Safe for all skin types including sensitive skin, and can be used on face, neck, décolletage, hands, and even under eyes.
Natural, Progressive Results Creates gradual, natural-looking improvements that enhance your skin's inherent quality rather than creating artificial-looking changes.
Biocompatible and Safe Highly purified and biocompatible with minimal risk of allergic reaction. DNA structure is similar across species, making salmon-derived PN safe for human use.
Long-Lasting Effects Results can last 6-12+ months as the treatment creates lasting improvements in skin structure and function.
What Polynucleotides Treat
Skin Concerns:
Fine lines and wrinkles
Loss of skin firmness and elasticity
Dull, tired-looking complexion
Dehydrated, dry skin
Uneven skin texture and tone
Enlarged pores
Sun damage and photoaging
Acne scarring and textural irregularities
Rosacea and chronic redness
Sensitive, reactive skin
Under-eye dark circles and crepiness
Thin, fragile skin
Loss of skin radiance and vitality
Environmental damage
Treatment Areas:
Face (full face or targeted zones)
Under-eyes and periorbital area
Neck and décolletage
Hands
Any area with skin quality concerns
Polynucleotides vs Other Treatments
Polynucleotides:
Bio-regenerative at cellular level
Repairs DNA and cellular damage
Strong anti-inflammatory effects
Improves skin quality and health
Progressive, natural results
Particularly effective for sensitive/rosacea-prone skin
Lasts 6-12+ months
No immediate volume
Hyaluronic Acid Fillers:
Immediate volumising effect
Adds structure and contour
Hydration through HA water-binding
Results visible immediately
Not specifically regenerative
Lasts 6-18 months
Focuses on volume, not cellular repair
PRP:
Uses your own blood growth factors
Stimulates collagen production
Natural healing response
Requires blood draw
More variable results (depends on blood quality)
Multiple treatments needed
Lasts 12-18 months
Profhilo:
High-concentration hyaluronic acid
Bio-remodelling and hydration
Spreads naturally through tissue
Specific injection technique
Excellent for hydration and laxity
Lasts 6-9 months
Focuses on hydration and bio-remodelling
PLLA Bio-Stimulators (Sculptra):
Synthetic collagen stimulator
Gradual volume restoration
Very progressive results (months)
Requires massage protocol
Lasts 2+ years
Primarily volumising, not cellular repair
Polynucleotide Advantage: Unique ability to work at DNA/cellular level with anti-inflammatory properties makes polynucleotides ideal for genuine tissue regeneration, particularly in sensitive skin or inflammatory conditions.
What to Expect
1. Consultation We'll assess your skin concerns, discuss your goals, and determine if polynucleotides are the right treatment for you. We'll create a customised treatment plan tailored to your specific needs.
2. Preparation Treatment areas are thoroughly cleansed and marked. A topical numbing cream is applied for 15-20 minutes to ensure your comfort, though polynucleotide injections are generally well-tolerated.
3. Treatment Technique Polynucleotides are injected using one of several techniques:
BAP (Bio-Aesthetic Points) Technique: Strategic injection points across treatment areas
Micro-Papule Technique: Multiple small superficial injections creating tiny bumps that absorb
Linear Threading: For areas requiring more coverage
Specific Protocols: Different products have recommended injection patterns
The procedure typically takes 20-40 minutes depending on treatment areas.
4. Post-Treatment You may have small bumps at injection sites (micro-papules) that typically absorb within 24-48 hours. A soothing treatment may be applied.
5. Treatment Course Optimal results typically require:
Initial Course: 2-4 treatments spaced 2-4 weeks apart
Maintenance: Every 6-12 months to sustain results
Some products: May show benefits with single treatments, but courses provide best outcomes
Aftercare & Healing
First 24 Hours
Keep treatment areas clean - gentle cleansing only
Avoid touching, rubbing, or massaging treated areas
Do NOT massage unless specifically instructed (unlike some treatments, polynucleotides typically should not be massaged)
No makeup for 12-24 hours minimum
Avoid strenuous exercise and activities that increase blood flow
No alcohol consumption
Sleep with head elevated to minimise swelling
Apply cold compresses gently if needed (10 minutes at a time)
Avoid extreme heat (saunas, steam rooms, hot baths, sunbeds)
Stay well-hydrated
First 48-72 Hours
Micro-papules (small bumps) at injection sites are normal and will absorb - do not try to massage them away
Continue gentle skincare with mild, fragrance-free products
Avoid active skincare ingredients (retinol, acids, vitamin C)
No swimming (chlorine or bacteria exposure)
Continue avoiding vigorous exercise for 48 hours
Protect from direct sun exposure
Avoid facial treatments or massages
Light mineral makeup may be applied after 24 hours if micro-papules have resolved
First Week
Gradually resume normal exercise after 48-72 hours
Avoid facial treatments including facials, peels, microdermabrasion, laser treatments
Avoid dental procedures if possible
Wear SPF 30-50 daily - sun protection is essential
Avoid other injectable treatments in the same areas
Can gradually reintroduce normal skincare after 5-7 days
Keep skin well-moisturised and hydrated
First 2-4 Weeks
Continue daily sun protection
Avoid other cosmetic procedures until cleared
Attend follow-up appointments as scheduled
Next treatment session typically scheduled 2-4 weeks after initial treatment
What's Normal During Healing
Small bumps (micro-papules) at injection sites for 24-72 hours - this is expected and normal
Mild swelling for 1-3 days
Slight redness at injection points
Tenderness to touch for 1-2 days
Possible light bruising (less common)
Feeling of fullness or tightness initially
Asymmetry during settling period
Important Note on Micro-Papules: The small bumps visible after treatment are normal and indicate proper product placement. They typically resolve within 24-48 hours as the polynucleotides are absorbed. Do not attempt to massage them - they will absorb naturally.
When to Contact Us
Contact us immediately if you experience:
Signs of infection (increasing redness, warmth, fever, pus, foul odour)
Severe pain not controlled by over-the-counter pain relief
Excessive or prolonged swelling beyond one week
Persistent micro-papules beyond one week
Skin discolouration or necrosis
Vision changes or severe headache (particularly with under-eye treatment)
Severe bruising that worsens
Any unusual symptoms or concerns
Timeline for Results
Immediate (Days 1-7):
Micro-papules visible for 24-72 hours
Slight plumping from product and hydration
Mild glow as inflammation subsides
Short-Term (Weeks 2-4):
Improved skin hydration and texture
Enhanced radiance and glow
Subtle improvement in skin quality
Reduction in redness (particularly beneficial for rosacea)
Medium-Term (Months 1-3):
Progressive collagen and elastin production
Improved firmness and elasticity
Reduction in fine lines
Enhanced skin tone and evenness
Continued improvement in texture
Long-Term (Months 3-6):
Optimal results as cellular regeneration peaks
Maximum improvement in skin quality
Enhanced resilience and barrier function
Sustained hydration and plumpness
Natural, healthy-looking skin
Duration:
6-12+ months: Results typically last, particularly with a full treatment course
Cumulative: Each treatment in a series builds upon previous results
Progressive: Many clients notice continued improvement even after completing treatment course
Important Notes:
Results are gradual and natural - not instant transformation
Multiple treatments provide best outcomes
Improvements continue developing between sessions
Skin quality enhancement rather than dramatic volumising
Frequently Asked Questions
Are polynucleotides safe? Yes, polynucleotides have an excellent safety profile. They're highly purified, biocompatible, and have been used in medical applications for years. The DNA structure is similar across species, making salmon/trout-derived PN safe for humans with minimal allergic reaction risk.
Where do polynucleotides come from? They're extracted from salmon or trout sperm (milt), which contains high-quality, pure DNA. The extraction process is highly sophisticated, removing all proteins and potential allergens, leaving only the purified polynucleotide molecules. This is completely safe and biocompatible.
Does the treatment hurt? Discomfort is generally minimal with numbing cream. You may feel slight pinching or stinging during injections. The needles used are very fine. Most clients find the treatment very tolerable.
What are the bumps after treatment? Small bumps (micro-papules) at injection sites are normal and expected with most polynucleotide treatments. They indicate proper product placement in the dermis. These typically absorb within 24-72 hours and should not be massaged unless specifically instructed.
How is this different from Profhilo? While both are bio-remodelling treatments, they work differently. Profhilo is high-concentration hyaluronic acid that spreads through tissue for hydration and laxity improvement. Polynucleotides work at a cellular/DNA level with anti-inflammatory and regenerative properties. They complement each other beautifully and can be used together.
Can polynucleotides help with rosacea or sensitive skin? Yes, this is one of polynucleotides' key strengths. Their powerful anti-inflammatory properties make them ideal for rosacea, sensitive skin, and inflammatory conditions. They calm redness, strengthen the skin barrier, and reduce reactivity.
How many treatments will I need? Most protocols recommend 2-4 initial treatments spaced 2-4 weeks apart for optimal results. Maintenance treatments every 6-12 months help sustain benefits. Some clients see improvements with fewer treatments, but courses provide best outcomes.
When will I see results? Some immediate glow and hydration is visible once swelling subsides (within days). Meaningful improvements develop over 2-4 weeks as cellular regeneration begins. Optimal results appear at 3-6 months as collagen production peaks. This is progressive improvement, not instant transformation.
How long do results last? Results typically last 6-12+ months, particularly with a full treatment course. Because polynucleotides create genuine tissue regeneration and cellular improvement, effects can be long-lasting. Maintenance treatments extend longevity.
Can I combine polynucleotides with other treatments? Yes, polynucleotides work excellently alongside other treatments. They can be combined with:
Profhilo or skin boosters (often alternated in treatment protocols)
Dermal fillers (for volume where needed)
Anti-wrinkle injections (spaced appropriately)
Microneedling, lasers, peels (with proper timing) We'll create a comprehensive treatment plan during consultation.
Are polynucleotides suitable for under-eyes? Yes, specific polynucleotide formulations (like Lumi Eyes, Plinest Eyes, Nucleofill Eyes) are designed for the delicate under-eye area. They're excellent for dark circles, crepiness, fine lines, and improving skin quality without adding excessive volume.
What's the difference between different polynucleotide brands? Different brands vary in concentration, molecular weight, purification methods, and recommended protocols. Some are designed for specific areas (eyes, face, body). All quality polynucleotide products provide bio-regenerative benefits, but formulations may be optimised for particular concerns. We'll recommend the best option for your needs.
Am I a good candidate? Most adults concerned about skin quality, aging, hydration, texture, or inflammation are excellent candidates. Polynucleotides are particularly beneficial for:
Sensitive or rosacea-prone skin
Those wanting skin quality improvement over volume
Preventative anti-aging (younger clients)
Compromised skin barrier
Sun damage and environmental aging Not suitable during pregnancy or breastfeeding, or with active infections or certain medical conditions.
Can polynucleotides cause allergic reactions? Allergic reactions are extremely rare due to the high purification process that removes proteins and potential allergens. However, as with any injectable treatment, there's always a minimal risk. We'll review your full medical history during consultation.
Do polynucleotides add volume like fillers? No, polynucleotides are not volumising fillers. While there may be slight plumping from hydration improvement, their primary function is bio-regeneration, cellular repair, and skin quality enhancement rather than structural volume addition.
What makes polynucleotides unique? Their ability to work at DNA/cellular level, combined with powerful anti-inflammatory properties, sets polynucleotides apart. They genuinely repair and regenerate tissue rather than just masking aging signs, making them ideal for addressing root causes of skin aging.
Why Choose Polynucleotides?
Perfect for clients who:
Want genuine cellular regeneration, not just surface improvement
Have sensitive skin, rosacea, or inflammatory conditions
Desire skin quality enhancement over volumising
Want anti-aging treatment with anti-inflammatory benefits
Are looking for biocompatible, natural-working treatments
Need skin barrier repair and strengthening
Want long-lasting improvements in skin health
Prefer progressive, natural-looking results
The Regenerative Revolution: Polynucleotides represent a new frontier in aesthetic medicine - working at the deepest cellular level to genuinely regenerate, repair, and restore your skin's health, vitality, and youthful function.
Ready to Regenerate Your Skin from Within?
Schedule your personalised consultation today to discover how polynucleotide treatments can transform your skin quality and restore youthful vitality.
